Original Article
Effect of atorvastatin on circulating adipocytokine levels in diabetic patients
Author(s): Alberto F Rubio-Guerra*, Hilda Vargas-Robles, German Vargas-Ayala, Cesar I Elizalde-Barrera, Montserrat B Duran-Salgado and Bruno A Escalante-Acosta PSC
BACKGROUND: Adipocytokines are adipocyte-secreted hormones that have a role in the effects of insulin, metabolism, endothelial function, vascular damage and cardiac disease. Statins have been shown to have cardioprotective effects and to modulate adipose tissue function; however, the effect of each statin on the circulating concentrations of adipocytokines varies.
OBJECTIVES: To evaluate the effect of atorvastatin on adipocytokine levels in normotensive patients with type 2 diabetes.
Methods: Twenty patients with type 2 diabetes and naive to statins and inhibitors of the renin-angiotensin systems received 10 mg atorvastatin once per day over a three-month period. Adiponectin and resistin levels were measured using ELISA at the beginning and conclusion of the study. Patients were evaluated monthly for blood pressure, fasting serum glucose levels, lipid profile and adver.. Read More»
DOI:
10.4172/2368-0512.1000045
