Perspective
Using IBS-based Haseman-Elston regression to estimate the heritability of complex characteristics from genome-wide association studies
Author(s): Aldous Huxley*
Statistical genetics' main objective is to investigate the heritability of complicated traits. The variance component approaches are favourable when estimating heritability using markers, compared to other previously proposed methods. The best suitable heritability estimator model is frequently ambiguous since data from genome-wide association studies, in which genetic architecture is frequently unknown, have a high degree of dimension. Initially primarily suggested for linkage research, the Haseman-Elston regression is a variance component technique. This study, however, provides a theoretical foundation for a modified HE that models linkage disequilibrium for a quantitative trait and can, thus, be used for GWAS. We applied the IBS-based HE regression to single-marker association studies (scenario I) and evaluated the variance component by employing multiple markers after substit.. Read More»
DOI:
10.37532/puljcgg.22.5(3) 1-2
