Reviews
Cardiac remodelling: General aspects and mechanisms
Author(s): Henrique Budib Dorsa Pontes*, Jose Carlos Dorsa Vieira Pontes, Euler de Azevedo Neto, Alexandre Henrique Zangari, Joao Victor Cunha Miranda and Otoni Moreira Gomes
The progression of heart failure is related to cardiac remodelling, which represents the sequence of events at the molecular, cellular and interstitial levels, leading to changes in the size, mass, geometry and function of the heart. Cardiac remodelling involves both adaptive and maladaptive phases of development. At the initial stage, it represents an adaptive response to maintain cardiac output, whereas in the late stage, it results in the occurrence of heart failure. Oxidative stress appears to be the main factor that induces transition of cardiac hypertrophy to heart failure as a consequence of alterations in signal transduction, dysfunction of the sarcolemma and sarcoplasmic reticulum, impairment of calcium handling, increases in cardiac fibrosis and progressive loss of cardiomyocytes. Elements that play a fundamental role at the initial stages of car.. Read More»
DOI:
10.4172/2368-0512.1000073
