Perspective
Carotid plaque rupture that results in stroke is accompanied by a transcriptome profile that is pro-inflammatory and thins the fibrous cap
Author(s): Arnold Winfield*
The cause of myocardial infarction and ischemic stroke is rupture of an atherosclerotic plaque. The paucity of information from plaques at the time of rupture contributes to the mystery surrounding the molecular mechanisms of rupture. Carotid plaques from patients undergoing carotid endarterectomy with high-grade stenosis and either (1) a carotid-related ischemic cerebrovascular event within the previous 5 days ('recently ruptured,' n=6) or (2) an absence of a cerebrovascular event were obtained. Ribosome-depleted total RNA was then sequenced from the carotid plaques. Plaque rupture was identified as the major contributor to sample variability (23.2%) by principal component analysis, and transcripts linked to inflammation and extracellular matrix breakdown were more abundant in recently ruptured plaques. Differentiating the asymptomatic from the freshly burst plaques was accom.. Read More»
DOI:
10.37532/pulcj.22.6(4).44-46
+447362049920
