Research Article
Effect of blood transfusion on TNFα, IL-1, and IL-6 cytokine gene expression in abdominal aortic aneurysm repair patients
Author(s): Azita Chegini, Samad Valizadeh, Shahram Samiee, Sara Zandpazandi and Faranak Behnaz*
BACKGROUND: An Abdominal Aortic Aneurysm (AAA or triple A) is a localized enlargement of the aorta in the abdominal region, with a diameter of 3 cm or more and also 50% larger than normal. AAA is the most common form of aortic aneurysm, about 85% of which occur below the kidneys, at the level, or above the kidneys. In case of aortic rupture, the patient's mortality rate will be 85% to 90%. It is estimated that about 0.2% of blood recipients have a systemic inflammatory response. Considering the vital need of aortic aneurysm patients for blood transfusion, we evaluated the gene expression changes of inflammatory cytokines such as interleukin 1 and 6 (IL-1 and 6) and Tumor Necrosis Factor α (TNF-α) in these patients before anesthesia, after anesthesia, at different intervals after transfusion until the patient's discharge time.
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DOI:
10.37532.6(1).01-06
