Original Article
High-carbohydrate diet-induced myocardial remodelling in rats
Author(s): Esma N Okatan, Sule Kizil, Hilal Gokturk, Belgin Can and Belma Turan*
BACKGROUND: A high-carbohydrate diet leads to the metabolic syndrome (MetS), which leads to an increased risk for cardiovascular dysfunction; however, the effect of high-carbohydrate diets on systemic metabolism has not yet been fully determined. It has been observed that abnormal fatty acid metabolism and increased oxidative stress play a role in the pathogenesis of MetS-related cardiovascular diseases.
OBJECTIVE: To examine the effects of high sucrose intake on left ventricular contractility and structure of heart tissue.
METHODS: MetS was induced in male rats with drinking water supplemented with 32% sucrose for 16 weeks. Oral glucose tolerance test results and parameters related to insulin resistance were used to validate MetS.
RESULTS: Body weight and blood glucose levels were higher in the MetS group compared with age-matched controls. The increased serum.. Read More»
DOI:
10.4172/2368-0512.1000020
