Perspective
Aphasia: the natural history of basic progressive aphasia
Author(s): Catherine Nichols*
Primary progressive aphasia (PPA) is split into three archetypal subtypes, each of which is defined by a single aphasia symptom. Although other cognitive, behavioural, and motor domains may become engaged later in their course, little is known about each subtype's progression profile in relation to the other subtypes. 24 patients diagnosed with semantic variant (svPPA), 22 with non-fluent variant (nfvPPA), and 18 with logopenic variant (lvPPA) were collected and followed up for 1–6 years in this longitudinal retrospective cohort study based on new biomarker-supported diagnostic criteria. The severity of symptoms, scores on cognitive tests and neuropsychiatric inventories, and development into another syndrome were all evaluated. Over time, lvPPA developed broader language issues (PPA-extended) and nfvPPA developed mutism, although semantic impairment remained the primary iss.. Read More»
DOI:
10.37532/pulnj.22.5(1).1-2
