Chuling Du

Publications

• Original Article   
  Preparation and study of the physicochemical properties of psoralen-doxorubicin nanostructured lipid carriers
  Author(s): Tiange Cai, Chuling Du, Yinghong Huang, Xi Xia and Yu Cai*
  
  The purpose of the present study was to prepare psoralen-doxorubicin nanostructured lipid carriers (PSO-DOX-NLC) with better physicochemical properties for further study on its multidrug resistance reversal activity on leukemia cells. PSO-DOX-NLC was synthesized by emulsion evaporation and solidification at a low temperature. PSO-DOX-NLC morphology and particle size were examined using transmission electron microscopy, and Zeta potential was determined using photon correlation spectroscopy; encapsulation efficiency was also investigated. The results showed that PSO-DOX-NLC possessed a rounded structure, with a mean (± SD) particle size of 128.7±1.8 nm, a polydispersity index of 0.22±0.01, a Zeta potential of 20.17±0.31 mV, a psoralen encapsulation rate of 76.56% and a doxorubicin encapsulation rate of 89.48%. Thus, PSO-DOX-NLC p.. Read More»
  DOI: 10.4172/2529-797X.1000009

  • Abstract
  • Full-Text
  • PDF