Perspective
Obesity and Cancer: A Possible role for dysregulated dietary phosphate
Author(s): Deniel Smith*
Obesity is the second-highest avoidable risk factor for cancer, behind smoking, but rising obesity and overweight rates are expected to replace smoking as the main preventable cancer risk factor. Few studies have looked at the dysregulated endocrine metabolism of dietary phosphate as a potential moderating element in the obesity-cancer link. Phosphate toxicity, or the build-up of excess phosphate in the body as a result of dysregulated phosphate metabolism, has been linked to cancer. Obesity is also associated with high levels of hormones that govern phosphate metabolisms, such as parathyroid hormone and fibroblast growth factor 23, suggesting a possible relationship between obesity and phosphate toxicity. Increased inorganic phosphate intake has been connected to an increase in the consumption of foods processed with phosphate additions, and consumption o.. Read More»
DOI:
10.37532/puljeds.2022.6(1)-001-002.
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