Original Article
Irisin levels increase during experimentally induced acute myocardial infarction
Author(s): Güney Sarioğlu, Hasan Korkmaz*, Ebru Önalan, Tuncay Kuloğlu, Mücahit Yilmaz, Murat Özgüler and Ertuğrul Kurtoğlu
Background: Irisin is a hormone involved in energy metabolism. To date, however, there are scant data regarding irisin levels in infarcted tissues.
Objective: To evaluate changes in irisin levels in the cardiac tissue of rats during experimentally induced myocardial infarction (MI).
Methods: A total of 21 rats, comprising three groups of seven animals each (MI-1, MI-2 and a control group), were used. Isoproterenol (150 mg/kg once daily for two days ) was used to induce acute MI. The rats in the MI-1 group were evaluated at the end of the first week after the development of MI; rats in MI-2 were evaluated at the end of the second week after the development of MI. Following decapitation, irisin levels in the removed cardiac tissue were examined using polymerase chain reaction and immunohistoch.. Read More»
DOI:
10.4172/2368-0512.1000055
