Commentary
Inflammatory bowel illness is associated with altered gut bacterial and metabolic profiles, as well as their interplay
Author(s): Edward Wagner*
The gut microbiome's dysregulation has been linked to the development of numerous illnesses. Using data from the Human Microbiome Project (HMP) and the Integrative Human Microbiome Project, this study investigated the role of microbial and metabolic signatures, as well as their interaction between patients with Inflammatory Bowel Disease (IBD) and Healthy Controls (HCs), using a combination of machine learning and traditional statistical analysis (iHMP). The microbiological and metabolic fingerprints of IBD patients were found to be considerably different from those of healthy controls. IBD sufferers had 25 enriched species and 6 deficient species as compared to HCs. In addition, 17 differentiating pathways were discovered between the IBD and HC groups. These distinct pathways were mostly engaged in amino acid, nucleotide, and carbohydrate production and breakdown. The non-predomi.. Read More»
DOI:
10.37532/ puljcmid.2022.5(3).24-25
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