Opinion
Changes in ovarian hormones, their receptors, and neuroendocrine function as people age
Author(s): Edward Williamson*
The menopause is the irreversible termination of a woman's fertility. The depletion of the ovarian follicle reserve was formerly assumed to be the only explanation for this drastic physiological shift. New evidence from women's studies and animal models leads us to rethink this notion. Multiple pacemakers, according to a growing body of data, play a role in the shift to irregular cycles, decreased fertility, and the timing of menopause. We will present evidence that supports the hypothesis that a dampening and desynchronization of precisely orchestrated neural signals causes miscommunication between the brain and the pituitary-ovarian axis, and that this constellation of hypothalamic-pituitary-ovarian events causes regular cyclicity to deteriorate and heralds menopausal transition. Because the ovarian follicle is not only the source of oocytes but also the primary source of es.. Read More»
DOI:
10.37532/puljeds.22.6(2).12-13
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