Perspective
An Integrative Model for the Emergence and Conservation of Minor Introns
Author(s): Ember Walsh*
Since their discovery, minor introns, which make up around 0.5% of the introns in the human genome, have been a mystery. The minor spliceosome, a unique splicing complex, eliminates these introns. Both have a long evolutionary history that dates back to the Last Eukaryotic Common Ancestor (LECA), as seen by minor intron enrichment in particular gene families such as the voltage-gated sodium and calcium ion channels, mitogen-activated protein kinases, and E2F transcription factors. In genes with a preponderance of major introns, the majority of minor introns are found as single introns. This arrangement increases the likelihood of missplicing since Minor Intron-Containing Gene (MIG) expression necessitates the coordinated action of two spliceosomes. Therefore, one would anticipate modest intron loss through purifying selection. At least nine eukaryotic lineages have experienced complet.. Read More»
DOI:
10.37532. puljcgg.22.5(2)1-2
