Mini Review
Caffeine is a stimulant LDLR-mediated cholesterol clearance is improved by SREBP2-induced hepatic PCSK9 expression
Author(s): Enrico Fasolato*
Caffeine (CF) appears to lower the risk of Cardiovascular Disease (CVD). The process by which this occurs, however, has yet to be discovered. The influence of CF on the expression of two genuine regulators of circulating Low-density Lipoprotein Cholesterol (LDLc) levels, the Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) and the Low-density Lipoprotein Receptor (LDLR), was studied in this study (LDLR). Following the discovery that CF decreased circulating PCSK9 levels while increasing hepatic LDLR expression, further CF-derived analogues with higher PCSK9 inhibitory potency than CF were created. The effect of CF on decreasing PCSK9 was later validated in a group of healthy individuals. We show that CF increases hepatic Endoplasmic Reticulum (ER) Ca2+ levels, which inhibits transcriptional activation of the Sterol Regulatory Element.. Read More»
DOI:
10.37532/pulcj.22.6(2).13-14
+447362049920
