Reviews
Effect of alpha-glucosidase inhibitors on progression of carotid intima-media thickness and incidence of diabetes in patients with impaired glucose tolerance: a meta-analysis
Author(s): Hnin Hnin Hlaing and Ge Xu*
BACkGRouND: Impaired glucose tolerance (IGT) is associated with increased cardiovascular risk. Little is known whether alpha-glucosidase inhibitors (alpha-GIs) can prevent the progression of carotid intima-media thickness (IMT) or the incidence of diabetes, and whether they have any effect on inflammatory biomarkers such as C-reactive protein (CRP) in IGT patients.
oBjECTIVE: To perform a systematic review on the effect of acarbose on carotid IMT, incidence of diabetes and CRP in patients with IGT.
METhoDS AND RESulTS: A meta-analysis of randomized controlled trials (RCTs) comparing acarbose with control group in prediabetes patients was conducted. Eleven RCTs with 2699 patients were included. Alpha-GI therapy was associated with a significant reduction in progression of carotid IMT (weighted mean difference –0.12 mm [95% CI –0.20 mm to –0.04 mm]; P&l.. Read More»
DOI:
10.4172/2368-0512.1000015
