Opinion
Addison's disease with autoimmunity
Author(s): James Adams*
A uncommon condition known as Autoimmune Addison Disease (AAD) is brought on by an immune system attack on the adrenal cortex. Autoantibodies against 21-hydroxylase (21-OH), a steroid enzyme expressed in the adrenal cortex, are frequently seen in patients with AAD. Adrenal steroid hormone insufficiency results from the adrenal glands being destroyed by the autoimmune onslaught. AAD is fatal if left untreated, however modern hormone replacement medication makes it possible to live. Treatment options include the replacement of glucocorticoids and mineralocorticoids, while the value of androgen replacement is questionable. Since existing oral replacement regimens produce intervals of supraphysiological and infraphysiological cortisol levels, the ideal glucocorticoid replacement therapy would replicate the natural diurnal cortisol cycle. However, this is not practical to do. To more accur.. Read More»
DOI:
10.37532/puljeds.22.6.4.16-17
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