Case Reports
Multiple central giant cell granuloma’s in the mandible - a rare presentation with literature review.
Author(s): Owen Abiola*, Srikrishn Patel, Josuloba Harries and Mannu Vempaty
Central giant cell granulomas (CGCG) are rare, benign destructive osteolytic lesion of osteoclastic origin with variable aggressiveness that occur in the maxilla and mandible. It has a peak prevalence between the ages of 10 to 25 years old with a clear preponderance for the mandible and female population. CGCG typically presents as a solitary lesion, appearing as a multilocular radiolucency with scalloped margins and a honeycomb or soap bubble like appearance. These lesions are histologically characterised by mononuclear and multinuclear giant cells on a mesenchymal stromal background. First reported by Jaffe the lesion was coined giant cell reparative granuloma; a term no longer used as understanding of the pathogenesis develops. Genetic sequencing has shown fam.. Read More»
DOI:
10.37532. puldcr-22.6.4.1-3
