Original Article
The effect of statin therapy on coronary atherosclerosis as assessed by computed tomography
Author(s): Darryl Wan, A. Yashar Tashakkor, Jonathon Leipsic, Paolo Raggi and G.B. John Mancini*
OBJECTIVES: The effect of statin therapy on coronary artery calcification is unclear. Early studies suggested a slower rate of coronary artery calcium score (CACS) progression, but recent prospective trials have failed to show this benefit. Recent studies have explored the use of Cardiac Computed Tomography Angiography (CCTA) to characterize plaque features. We provide a systematic review of available literature documenting the effects of statin therapy on the progression of CACS and non-calcium-based indices. METHODS: A systematic search was performed from January 1, 1980 to April 28, 2016 using these databases: Cochrane Database, ACP Journal Club, Health Technology Assessment, Embase, NHS Economic Evaluation Database, Ovid MEDLINE, Health and Psychosocial Instruments. English language publications that serially measured relationships between statin thera.. Read More»
DOI:
10.4172/2368-0512.1000077
