Original Article
Safety, tolerability and efficacy of ivabradine for control of sinus tachycardia in patients undergoing inotropic therapy
Author(s): Rafael Porcile, Ricardo Levin*, Osvaldo Fridman, Gabriel Perez Baztarrica, Sebastian Villeco, Flavio Salvaggio, Norberto Blanco and Alejandro L Botbol
OBJECTIVES: To assess the safety, tolerability and efficacy of ivabradine administered to patients experiencing decompensated heart failure who were undergoing inotropic therapy and developed undesirable sinus tachycardia.
METHODS: The present study prospectively included consecutive patients with ischemic-necrotic cardiomyopathy and an ejection fraction <35% who were admitted for decompensated heart failure while undergoing inotropic therapy and developed undesirable sinus tachycardia. Patients experiencing shock, or requiring respiratory or circulatory mechanical support, or those presenting with a heart rhythm other than sinus were excluded. Hemodynamic measurements using a pulmonary artery catheter were performed before and 3 h after an oral dose of 15 mg of ivabradine. Adverse side effects and tolerance wer.. Read More»
DOI:
10.4172/2368-0512.1000056
