Reviews
Reversing subcellular remodelling in the rescue of depressed contractility
Author(s): Ellis A Christian, Yenal I Harper, Salvatore Mancarella, Rohan Goswami, Beatrix M Ramos and Karl T Weber*
Systolic heart failure with reduced ejection fraction has long been regarded as a heart with an irreversible depression in myocardial contractility. Improvements in ventricular function with recovery of contractility, however, have occurred during a period of cardiac unloading provided by a continuous-flow left ventricular assist device. The authors briefly review subcellular remodelling involved in the appearance of depressed cardiomyocyte work. Redox-sensitive deiodinase 3 (Dio3) is held responsible for a reduction of intracellular thyroid hormone signalling with the re-expression of a fetal gene program that includes slow β-myosin heavy chain. The attendant reduction in contractile work is an adaptation that preserves myocyte efficiency (work/energy consumed) and viability. Neutralizing oxidative stress and Dio3 is integral to the reversal of subce.. Read More»
DOI:
10.4172/2368-0512.1000072
