Perspective
Role of cystatin C in alzheimer's disease
Author(s): Shawn Kruger*
A function for CysC in these situations is supported by changes in cystatin C (CysC) expression and secretion levels in the brain associated with a variety of neurological illnesses and in animal models of neurodegeneration. Alzheimer's disease risk is elevated by a variation in the CysC gene (CST3) (AD). The pathogenesis of AD is characterised by neurodegeneration, neurofibrillary tangles made primarily of hyperphosphorylated tau, and the deposition of oligomeric and fibrillar forms of Amyloid (A) in the walls of the cerebral artery and neuropil. CysC's co-localization with A in amyloid-laden vascular walls and in senile plaque cores of amyloid in the brains of patients with AD, Down's syndrome, Hereditary Cerebral Haemorrhage With Amyloidosis, Dutch Type (HCHWAD), and cerebral infarction initially raised questions about its potential role in the disease. CysC's co-l.. Read More»
DOI:
10.37532/puljcpn.2022.5(6).70-1.
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