Opinion
SARS-CoV-2 S glycoprotein: Synthesis, processing, and trafficking
Author(s): Smith Wese*
The Rough Endoplasmic Reticulum (RER), the SARS-CoV-2 S glycoprotein is produced as a 1273-amino-acid polyprotein precursor. At the N terminus of the unprocessed precursor is an Endoplasmic Reticulum (ER) signal sequence, which directs the S glycoprotein to the RER membrane and is degraded by cellular signal peptidases in the ER lumen. The S protein’s C terminus has a single stop-transfer, membrane-spanning motif that inhibits it from being fully released into the ER lumen and subsequent secretion from the infected cell. During synthesis, N-linked, high-mannose oligosaccharide side chains are added co-translationally. The S glycoprotein monomers trimerize shortly after synthesis, which may help in transport from the ER to the Golgi complex. Most high-mannose oligosaccharide side chains are changed to more complex forms in the Golgi complex, and O-linked oligosaccharide side chai.. Read More»
DOI:
10.37532/puljbb.22.6(1).02
+447723860698
