Mini Review
Renal Biology-Driven Macro- And Microscale Design Strategies For Fiber-Based Technologies To Create An Artificial Proximal Tubule
Author(s): Stacy Miller*
One in every six people in the world suffers from chronic renal disease. A cell-based bioartificial kidney (BAK) device is required due to the paucity of donor kidneys and the problems associated with hemodialysis (HD). One of HD's flaws is that it lacks active solute transport, which is generally carried out by membrane transporters in kidney epithelial cells. Proximal tubule epithelial cells, in particular, play a key role in the active transfer of metabolic waste products. As a result, a BAK with an artificial PT capable of actively transporting solutes between the blood and the filtrate could offer significant therapeutic benefits. A biocompatible tubular framework that supports the adhesion and function of PT-specific epithelial cells is required to create such an artificial PT. This scaffold should, in theory, structurally mimic the natural PT basement membrane, which is pri.. Read More»
DOI:
10.37532/pulcnr.22.6(1).1-2
+447362049920
