Original Article
Experience with cellular and antibody mediated rejection after heart transplantation
Author(s): Ivan Málek*, Tomáš Gazdic, Markéta Hegarová, Lud ek Voska, Libuše Pagácová, Josef Kautzner and Jan Pirk
Objectives: To evaluate celluar and antibody mediated rejection in a group of patients after heart transplantation (HTX), performed in the authors’ institution during a six-year period.
Method: A retrospective analysis of patients surviving ≥12 months after HTX was performed. Rejection was evaluated from the samples obtained during endomyocardial biopsy, and graft function was assessed using echocardiography. The duration of follow-up ranged from 12 to 72 months.
Results: In the 196 patients evaluated, 65 treated episodes of cellular rejection were recorded in 50 patients, with significant reduction on tacrolimus prophylaxis. Antibody mediated rejection occured in 5.6% of patients, and was complicated by graft dysfunction in 64%.
Conclusion: Contemporary immunosuppressive prophylaxis decreases the frequency of cellular rejection, allowing modification .. Read More»
DOI:
10.4172/2368-0512.1000036
