Original Article
Investigation of the cardioprotective effects of Crataegus oxycantha and its molecular mechanism
Author(s): Harshul Parikh*, CB Tripathi, Prakash Shah, Vijay Ghori and Ramesh K Goyal
BaCKGRound: Crataegus oxycantha has been used as a cardiotonic for the treatment of early stage congestive heart failure; however, there are few authentic investigational studies addressing its cardioprotective use.
oBJECTIVE: To investigate the cardioprotective effect of C oxycantha and to elucidate its possible mechanism of action.
METHodS: The effects of C oxycantha was studied using a rat model of isoproterenol (ISO) (100 mg/kg subcutaneous for two days) -induced myocardial necrosis. Cardiac damage was assessed using various biochemical enzymes and histological studies. Various oxidative parameters and Na+-K+ ATPase activity were studied to elucidate the mechanism of action.
RESulTS: Pretreatment with C oxycantha significantly prevented the increase in serum levels of cardiac troponin-I, creatine kinase-MB, lactate dehydrogenase, glutamate oxalotransaminase.. Read More»
DOI:
10.4172/2368-0512.1000044
