Perspective
Role of CRTH2 in Eosinophil Infiltration of Recurrent Nasal Polyps
Author(s): Xin Feng*
Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a difficult-to-treat disease that is often characterized by recurrent nasal polyp (NP) growth even following surgical removal, but the mechanisms that underlie the pathogenesis of polyp recurrence are still not clear.
Objectives: This study aimed to investigate the expression of chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) receptor on eosinophils of patients with nasal polyps and the role it plays in eosinophil infiltration and nasal polyp recurrent.
Methods: mRNA was extracted from recurrent nasal polyp, nasal polyps, control group and evaluated for expression of CRTH2. Immunofluorescence staining was performed to confirm theexpression of CRTH2 protein. CRTH2 expression on peripheral blood eosinophils was quantifi.. Read More»
DOI:
10.37532/pulgsoa.2022.5(1)-01
