Original Article
Short-term effects of varenicline therapy on homogeneity of heart rate, atrioventricular conduction and ventricular repolarization
Author(s): Yusuf Karavelioğlu, Hekim Karapınar, Macit Kalçık*, Zekeriya Küçükdurmaz, Sultan Ã?Â?zkurt and Taner Sarak
Background: The effects of varenicline, an effective drug for smoking cessation, on atrioventricular and ventricular conductance remain unknown.
Objective: To evaluate the effects of varenicline on heart rate, PR interval, QT interval and QT dispersion (QTd). Meth ods: A total of 60 smokers were prospectively enrolled in the present study. Twelve-lead electrocardiogram recordings were obtained for all subjects before and on the 15th day of drug administration. Electrocardiograms were recorded at an amplitude of 20 mm/mV and a sweep speed of 50 mm/s. \
Results : The mean (± SD) age of the volunteers was 38±10 years. Thirtyfour (57%) were male. Fourteen (23%) had hypertension, eight (13%) had diabetes and six (10%) had chronic obstructive pulmonary disease. The mean heart rate was 74.7±13.3 beats/min, and mean systolic and diastolic blood pressures o.. Read More»
DOI:
10.4172/2368-0512.1000033
