Atrial Natriuretic Peptide
Atrial symptom peptide (ANP) or chamber symptom issue (ANF) could also be a symbol amide secretion secreted from the interior organ atria that in humans is encoded by the NPPA cistron. symptom peptides (ANP, BNP, and CNP) square measure a family of hormone/paracrine factors that square measure structurally connected. the foremost operate of ANP is inflicting a reduction in distended liquid body substance (ECF) volume by increasing urinary organ number 11 excretion. ANP is synthesized and secreted by memory muscle cells within the walls of the atria within the guts . These cells contain volume receptors that reply to inflated stretching of the chamber wall because of inflated chamber blood volume.
Reduction of blood volume by ANP may find yourself in secondary effects like reduction of liquid body substance (ECF) volume (edema), improved viscus ejection fraction with resultant improved organ insertion, attenuate force per unit area, and inflated liquid substance K. These effects could even be dull or negated by varied counter-regulatory mechanisms operative at an equivalent time on every of these secondary effects.
Brain symptom amide (BNP) – a misnomer; it's secreted by memory muscle cells within the guts ventricles – is like ANP in its result. It acts via the same receptors as ANP will, however with 10-fold lower affinity than ANP. The biological half-life of BNP, however, is double as long as that of ANP, which of NT-proBNP is even longer, creating these peptides higher decisions than ANP for diagnostic blood testing.
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