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Drug-Induced Liver Injury

 Drug-induced liver injury (DILI) is associate uncommon, however probably fatal, reason behind disease that's associated with prescription medications, OTC drugs, and seasoner and dietary supplements (HDS). DILI has 2 types: intrinsic and individual. Patient, environmental, and drug-related factors might play a task within the pathological process of DILI. within the us, antibiotics and anticonvulsant medicine area unit the foremost common drug categories associated with DILI, however HDS area unit on the rise as a cause. Management of DILI involves the removal of the offensive agent and also the utilization of N-acetylcysteine for acetaminophen-induced liver injury. Outcomes vary relying on the drug used and type of liver injury sustained. Pharmacists will play a necessary role within the analysis of DILI, particularly in patients taking multiple medications and supplements. Drug-induced liver injury (DILI; conjointly mentioned as drug-induced hepatotoxicity) is caused by medications (prescription or OTC), seasoner and dietary supplements (HDS), or alternative xenobiotics that end in abnormalities in liver tests or in viscus pathology that cannot be explained by alternative causes.1 There area unit 2 sorts of DILI: intrinsic and individual. Intrinsic DILI refers to liver toxicity evoked by a drug during a very sure and dose-related manner (e.g., acetaminophen [APAP]); individual DILI, that happens less oft, is said to a less consistent dose-toxicity relationship and a tons of various presentation.

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