Human Epidermal Growth Factor Receptor
The epidermal growth factor family of receptor tyrosine kinases (ErbBs) plays essential roles in regulating cell proliferation, survival, differentiation and migration. The ErbB receptors carry out both redundant and restricted functions in mammalian development and in the maintenance of tissues in the adult mammal. Loss of regulation of the ErbB receptors underlies many human diseases, most notably cancer. Our understanding of the function and complex regulation of these receptors has fueled the development of targeted therapeutic agents for human malignancies in the last 15 years. Here we review the biology of ErbB receptors, including their structure, signaling, regulation, and roles in development and disease, then briefly touch on their increasing roles as targets for cancer therapy. Growth factors are essential for the development, growth and homeostasis of multicellular organisms. Acting through cell surface receptors, growth factors are required for cell-cell communications underlying embryonic tissue induction, fate determination, cell survival, apoptosis, tissue specialization and cell migration. Growth factor receptors transduce extracellular signals through the activation of intracellular messengers or directly through receptor translocation to the nucleus. Of the receptor tyrosine kinases (RTKs), the epidermal growth factor (EGF) family of RTKs, also called ErbB or HER receptors, is one of the most extensively studied for its role in development, physiology, and human cancer.
High Impact List of Articles
-
Ultrasound Guided Axillary Block for Upper Limb Surgery, Rural Experience
Rabesalama Fanojomaharavo T*, Randrianjaka H F, Randriamarolahy A H, Riel AM, Rajaonera AT Research Article: Anesthesiology Case Reports
-
Ultrasound Guided Axillary Block for Upper Limb Surgery, Rural Experience
Rabesalama Fanojomaharavo T*, Randrianjaka H F, Randriamarolahy A H, Riel AM, Rajaonera AT Research Article: Anesthesiology Case Reports
-
Anesthesia and Critical Care Outbreaks the Innovations in the Field of Anesthesiology
Steven J. Fowler Editorial: Anesthesiology Case Reports
-
Anesthesia and Critical Care Outbreaks the Innovations in the Field of Anesthesiology
Steven J. Fowler Editorial: Anesthesiology Case Reports
-
Conference Announcement of 6th World Nursing and Nursing Care
Congress
Rabie'e Al Rashdi Editorial: Anesthesiology Case Reports
-
Conference Announcement of 6th World Nursing and Nursing Care
Congress
Rabie'e Al Rashdi Editorial: Anesthesiology Case Reports
-
Spinal cord at the conus medullaris for treatment refractory pudendal: a case report
Tylor W, W Pzko Case Reports: Anesthesiology Case Reports
-
Spinal cord at the conus medullaris for treatment refractory pudendal: a case report
Tylor W, W Pzko Case Reports: Anesthesiology Case Reports
-
Anaesthetic management of a case of large retroperitoneal leiomyosarcoma
Siva Kumar Segaran*, Ranjan RV, Nikithamani Allen and Vikasini Raman Case Reports: Anesthesiology Case Reports
-
Anaesthetic management of a case of large retroperitoneal leiomyosarcoma
Siva Kumar Segaran*, Ranjan RV, Nikithamani Allen and Vikasini Raman Case Reports: Anesthesiology Case Reports
-
Perioperative management of a caesarean section in a patient with isolated pulmonic stenosis and severe pre-eclampsia
Nirmal Sheshagiri*, Salman Mohammad Kutty Chenath, Dinesh Raju and Supriya Preman Thazhath Pullayikudi Case Reports: Anesthesiology Case Reports
-
Perioperative management of a caesarean section in a patient with isolated pulmonic stenosis and severe pre-eclampsia
Nirmal Sheshagiri*, Salman Mohammad Kutty Chenath, Dinesh Raju and Supriya Preman Thazhath Pullayikudi Case Reports: Anesthesiology Case Reports
Conference Proceedings
-
IgG1 anti-PC reduces CVD risk in SLE patients by efficiently clearing apoptotic cells
Thiagarajan D, Frostegard A and Frostegard J Posters & Accepted Abstracts: Journal of Clinical Diagnosis and Treatment
-
IgG1 anti-PC reduces CVD risk in SLE patients by efficiently clearing apoptotic cells
Thiagarajan D, Frostegard A and Frostegard J Posters & Accepted Abstracts: Journal of Clinical Diagnosis and Treatment
-
Faddy diets, vegan diets and healthy eating in CKD: Which do you choose for your patient?
Ruth Kander Keynote: Journal of Clinical Diagnosis and Treatment
-
Faddy diets, vegan diets and healthy eating in CKD: Which do you choose for your patient?
Ruth Kander Keynote: Journal of Clinical Diagnosis and Treatment
-
Therapeutically targeting angiogenesis: Characteristics of tumor-associated endothelial cells and a new mechanism of resistance to bevacizumab
Candece L Gladson ScientificTracks Abstracts: Clinical Cardiology Journal
-
Therapeutically targeting angiogenesis: Characteristics of tumor-associated endothelial cells and a new mechanism of resistance to bevacizumab
Candece L Gladson ScientificTracks Abstracts: Clinical Cardiology Journal
-
The effects of a combined Bryophyllum pinnatum, Moringa olefeira and vitamin C phytotherapeutic agent on cholesterol levels
Alfred Sparman ScientificTracks Abstracts: Clinical Cardiology Journal
-
The effects of a combined Bryophyllum pinnatum, Moringa olefeira and vitamin C phytotherapeutic agent on cholesterol levels
Alfred Sparman ScientificTracks Abstracts: Clinical Cardiology Journal
-
The in-hospital financial burden of hidradenitis suppurativa in patients with inflammatory bowel disease
Alvaro J Ramos-Rodriguez, Ali Khan, Lauren Bonomo, Dmitriy Timerman, Yiming Luo and Alejandro Lemor Posters & Accepted Abstracts: Journal of Skin
-
The in-hospital financial burden of hidradenitis suppurativa in patients with inflammatory bowel disease
Alvaro J Ramos-Rodriguez, Ali Khan, Lauren Bonomo, Dmitriy Timerman, Yiming Luo and Alejandro Lemor Posters & Accepted Abstracts: Journal of Skin
-
Association between lipid profile and serum testosterone in patients with hirsutism disease
Sohail Waheed, Abdus Sattar, Muhammad Ahmad, sadiq ullah and Tanveer Syed Posters & Accepted Abstracts: Journal of Skin
-
Association between lipid profile and serum testosterone in patients with hirsutism disease
Sohail Waheed, Abdus Sattar, Muhammad Ahmad, sadiq ullah and Tanveer Syed Posters & Accepted Abstracts: Journal of Skin
Relevant Topics in Medical Sciences
+44 7362 04 9920
