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Metformin

Metformin is generally well tolerated. Common adverse effects include diarrhea, nausea, and abdominal pain. It has a coffee risk of causing low blood glucose. High blood lactic acid level is a concern if the medication is used in overly large doses or prescribed in persons with severe kidney problems. It is not recommended in those with significant disease. While no clear harm comes from use during pregnancy, insulin is usually preferred for gestational diabetes. Metformin is a biguanide antihyperglycemic agent. It works by decreasing glucose production by the liver, by increasing the insulin sensitivity of body tissues, and by exerting an anorexiant effect, thereby reducing caloric intake. Metformin was discovered in 1922. French physician Jean Sterne began study in humans in the 1950s. It was introduced as a medication in France in 1957 and the United States in 1995. It is on the planet Health Organization's List of Essential Medicines, the safest and best medicines needed during a health system. While no clear harm comes from use during pregnancy, insulin is usually preferred for gestational diabetes. Metformin is a biguanide antihyperglycemic agent. It works by decreasing glucose production by the liver, by increasing the insulin sensitivity of body tissues, and by exerting an anorexiant effect, thereby reducing caloric intake.

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