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Shinya Tajima
National Hospital Organization Shizuoka Medical Centre, Japan
Keynote: J Nurs Res Pract
In woman’s health and palliative care, breast cancer is world-threatening disease so important for treatment. In breast tumour especially papillary lesions reveal broad range from benign to malignant. If pathologists can accurately diagnose benign, reduce unnecessary operation. However pathologists tend to over diagnosis in papillary lesions. Here, we would like to present new concept of two papillary lesions at a glance benign. In the past, lacking my epithelial cells is thought to be invasion and means malignancy. Two cases of 68- (Case1) and 44-year-old (Case2) female are presented. They have abnormality in the breast. And they came to the hospital for further examination and treatment. Radiologically, malignancy could not completely exclude. Then, breast excision was performed. Histologically, both cases revealed papillary neoplastic lesions lined by fibrovascular core and nuclear inverse-polarity without atypia. Loss of myoepithelial cells was observed by HE, p63, and calponin. Previous report indicate CK5/6, ER, p63 and MUC3 are important for distinguishing between papillary lesions according to the differential index (based on Allred score) of ([ER total score] + [MUC3 total score])/([CK5/6 total score] + [p63 total score] + 1). Based on this analysis, our 2 cases had benign lesions. Additionally, the Ki-67 index was <1% in both cases, and no evidence of disease was observed minimum 62 months of followup for both cases, despite lack of additional treatment. Thus, we propose these lesions accurately benign and contributing Woman’s health and palliative care for reducing operation. Then these lesions are reported and named “Nuclear inverse polarity papillary lesion lacking myoepithelial cells”. However, the name is too long and its distinctiveness and rareness, someone think this tumor as “Tajima tumor” as for the advocator. Thus we can contribute to woman’s health by the viewpoint of pathological knowledge.
Recent Publications :
1. Shinya Tajima, Ichiro Maeda, Yoshihide Kanemaki, Yasuo Nakajima, Shinobu Tatsunami, Mamoru Fukuda and Masayuki Takagi. Evaluation of CD56 and CD57 Immunostainings for Discrimination between Endocrine Ductal Carcinoma In Situ and Intraductal Papilloma. Pathology International 2010; 60: 459-465.
2. Shinya Tajima, Yoshihide Kanemaki, Yasuyuki Kurihara, Kyoko Okamoto, Hiroshi Shimamoto, Hiroko Okazaki, Itsuko Okuda, Futoshi Kawahara, Yasuo Nakajima, Mamoru Fukuda and Ichiro Maeda. A Case of a Fibroadenoma Coexisting with an Invasive Lobular Carcinoma in the Breast. Breast Cancer 2011; 18: 319-323
3. Shinya Tajima, Ichiro Maeda, Yasuyuki Kurihara, Miyuki Fukushima, Yoshihide Kanemaki, Hiroshi Shimamoto, Keiko Kishimoto, Tomoko Uejima, Koichiro Tsugawa and Yasuo Nakajima. A Case of a Secretory Carcinoma of the Breast: Radio-Pathological Correlation. Edited by Nachiko Uchiyama and Marcelo Zanchetta Do Nascimento. Mammography Recent Advances by INTECH 2012: 389-398
Shinya Tajima graduated from Keio University School of Medicine, and was employed as a staff to Department of Pathology at Keio University School of Medicine. There he learned pathological anatomy and diagnostic pathology. After two years, he belong to Department of Radiology at St. Marianna University School of Medicine to study breast imaging. And he have presented some scientific exhibitions about radio-pathological correlation of the breast in domestic and international congress. Furthermore, he learned at St. Marianna University Graduate School of Medicine for four years. And after PhD of radiolo-pathology was acquired, now he is doing some research about the comparison of pathologic features and radiologic imaging findings and also using pathological knowledge as a staff of St. Marianna University School of Medicine Department of Pathology and Radiology. Now, he is interested in breast diagnostic pathology, breast radiologic pathology and working as a staff in National Hospital Organization Shizuoka Medical Center.
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