Obstetric outcomes of assisted reproduction in advanced maternal age

6^th World Congress on GYNECOLOGY AND OBSTETRICS

June 20-21, 2022 | Paris, France

Anna Rubinshtein

Leleka Maternity Hospital, Ukraine

Posters & Accepted Abstracts: J Reprod Biol Endocrinol

Abstract :

Statement of the Problem: In recent years, the number of women who give birth for the first time in advanced maternal age (AMA) after assisted reproduction (ART) has increased significantly. Pregnancy and childbirth in this population usually proceed with a large number of complications and require special tactics of follow-up and delivery. The purpose of this study is to investigate the impact of AMA and ART on obstetric outcomes of nulliparous singleton cephalic pregnancies and determine possible measures for the prevention of obstetric complications in AMA women after ART Methodology & Theoretical Orientation: A retrospective statistical analysis of medical recorders of live-born singletons, cephalic, non-anomalous nulliparous pregnancies was done. The ART conception and spontaneous conception groups were compared and contrasted. Findings: Intrauterine growth restriction, nonreassuring fetal state, induction of labor, operative vaginal delivery, C-section and massive obstetric hemorrhage (MOH) are authentically more common for the nulliparous ART-conception AMA patients, especially in the subgroup aged of 40-45 years. Conclusion & Significance: Nulliparous AMA women after ART have significantly higher risks of the adverse obstetric complications, and therefore require dynamic monitoring of the mother`s and fetal conditions, timely prevention and correction of disorders during pregnancy and delivery. Recommendation: These made to the maternity hospitals to consider this population as highly threatening for C-section and MOH and use uterotonics and hemostatics for prevention of the complications. Taking into account that the risk of complications significantly increases in patients aged 40 years and older, the option of the elective term C-section also should be considered for this subgroup of patients. References: 1. Waldenström U (2016). Postponing parenthood to advanced age. Upsala Journal of Medical Sciences. 121(4):235–43. doi:10.1 080/03009734.2016.1201553 2. Londero AP, Rossetti E, Pittini C, Cagnacci A, Driul L (2019). Maternal age and the risk of adverse pregnancy outcomes: a retrospective cohort study. BMC Pregnancy and Childbirth. 19(1). doi:10.1186/s12884-019-2400-x 3. Lean SC, Derricott H, Jones RL, Heazell AEP (2017). Advanced maternal age and adverse pregnancy outcomes: A systematic review and meta-analysis. PLOS ONE. 12(10), e0186287. doi:10.1371/journal.pone.0186287