Peculiarities of the course of Juvenile Arthritis depending on the polymorphism of Proinflammatory Cytokine genes

2^nd World Congress on PEDIATRICS AND CHILD CARE

November 06-07, 2019 | Tokyo, Japan

Artsymovych A

Shupyk National Medical Academy of Postgraduate Education, Ukraine

Posters & Accepted Abstracts: J Child Adolesc Psych

Abstract :

Introduction: The change in the nature of treatment led to a significant change in the course of juvenile idiopathic arthritis (JIA). Among the DMARDs, the antifolate drug methotrexate (MTX) retains its positions. The main therapeutic targets for biological therapy are pro-inflammatory cytokines (interleukin 1, 6 (IL-6), tumor necrosis factor α (TNF-α)). The dependence of the course and possibilities of JIA therapy on genetic features has not been studied enough.

Conclusion: The study of the genes IL6(G-174C), TNFα(G308A) and MTHFR may suggests some features of the course of the disease, which may allow optimizing and individualizing its treatment.

Biography :

E-mail: wintermdp@gmail.com