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Dr. R. R. Rakhimov
Republican Clinical Oncological Dispensary, Ufa, Russia
Posters & Accepted Abstracts: J Hepato Gastroenterol
Gastric cancer is one of the most common malignant neoplasms. The available targeted strategies give hope for antitumor treatment. There are not enough options for the treatment of advanced stomach cancer yet. The study of qualitative and quantitative characteristics of matrix metalloproteinases and their inhibitors is a promising direction of fundamental research, which will allow developing new approaches to the diagnosis and prediction of the appearance of gastric cancer diseases. The genes of matrix metalloproteinases and their inhibitors, as well as for many other genes, are characterized by polymorphism. The analysis of the frequency distribution of alleles and genotypes of polymorphic loci rs1799750 and rs494379 of the MMP1 gene, rs2285053 of the MMP2 gene, rs3025058 of the MMP3 gene, rs3918242 and rs17576 of the MMP9 gene, rs2276109 of the MMP12 gene, rs8179090 of the TIMP2 gene and rs9619311 of the TIMP3 gene in 314 patients diagnosed with gastric cancer, as well as in 339 unrelated healthy individuals living on the territory of the Republic of Bashkortostan. It was shown that the markers of increased risk of gastric cancer for Tatars are the genotypes rs1799750*1G/2G of the MMP1 gene and rs2276109*A/A of the MMP12 gene, for Russians – the genotype rs9619311*T/T of the TIMP3 gene. Associations of the rs494379*G allele of the MMP1 gene with the risk of developing malignant gastric tumors in men were found. Using the APSampler algorithm, combinations of alleles/genotypes associated with an increased as well as a reduced risk of developing gastric cancer were identified. The results confirm the influence of the studied polymorphic variants of matrix metalloproteinase genes and their tissue inhibitors on the risk of gastric cancer and are important for understanding the genetic structure of the pathology under study. Keywords: stomach cancer, matrix metalloproteinases, tissue inhibitors of matrix metalloproteinases, polymorphic variant of genes.
