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Amany Hussein Abolmagd Ahmed Ragab
Cairo University, Egypt
ScientificTracks Abstracts: J Neurol Clin Neurosc
Background: In Egypt, the characterization of Neuromyelitis Optica Spectrum Complaint (NMOSD) is deficient. Objectives: To estimate the demographics, clinical features, aquaporin4 antibodies (AQP4-IgG) status, and neuroimaging of Egyptian NMOSD patients. Methods: Retrospective analysis of 70 NMOSD patients' records were attained from the MS clinic, Kasr Alainy clinic, during January 2013 and June 2018. Results: Patients 'mean age was34.9 ±9.2 times, and the mean at complaint onset was28.9 ±10.5 times. Fifty-nine cases had an original monosymptomatic donation. AQP4-IgG was measured using either enzyme- linked immunosorbent assay (ELISA) (22 patients) or cell- grounded assay (CBA) (34 patients). Six and 29 patients had shown positive results, independently (p ˂0.001). 84 had typical NMOSD brain lesions. Longitudinally expansive myelitis was detected in 49 patients, and 9 had either short parts or normal cords. Treatment failure was advanced in seropositive patients. Rituximab significantly reduced the annualized relapse rate (ARR) compared to Azathioprine with a chance reduction of (76.47 ±13.28) and (10.21 ±96.07), independently (p = 0.04). Age at complaint onset was the only independent predictor for disability (p ˂0.01). Conclusion: Treatment failure was massive in seropositive patients. Still, there was no difference in clinical or radiological parameters between seropositive and seronegative patients. Patients, who were polysymptomatic or with aged age of onset, were prognosticated to have advanced unborn disability anyhow of the AQP4-IgG status.
Recent Publications :
1. Najib Kissani, Laila Liqali, Khaoula Hakimi, Jacob Mugumbate, Daniel Gams Massi, Eetedal Ahmed A. Ibrahim, Enat Yewnetu, Mofou Belo, Jo Wilmshurst, Pascal Mbelesso, Amany Hussein Ragab, Athanase Millogo, Leone Massimo. Why does Africa have the lowest number of Neurologists and how to cover the Gap?. December 2021. Journal of the Neurological Sciences 434(13):120119. DOI: 10.1016/j.jns.2021.120119.
2. Ragab AH, Kishk NA, Hassan A, et al. Changes in migraine characteristics over 30 days of Ramadan fasting: A prospective study. Headache. 2021;00:1-6. Doi: 10.1111/head.14231.
3. Kissani, N., El Khiat, A., Watila, M. M., El Aarroumi, I., Wahba, H. M., Emara, T. H., Eliashiv, D., Kissani, I., Gams Massi, D., Jabang, J. N., Ragab, A. H., & El Khiat, A. (2022). How New Technologies Could Help Improve Healthcare, Teaching, and Sensitization During Pandemics Like COVID-19. In K. Kahime, M. Zahir, M. Hadach, M. El Hidan, & B. Bougadir (Ed.), Public Health and Economic Resiliency in the Post-COVID-19 Era (pp. 86-104). IGI Global. DOI :10.4018/978-1- 7998-8202-2.ch006
Amany Hussein Abolmagd Ahmed Ragab is a Lecturer in Neurology in Kasr al-Ainy hospital. She is a member of the American Academy of Neurology, MDS, Member of the Egyptian Society of Neurology, Psychiatry, and Neurosurgery and Member of the International Child Neurology Association (ICNA Pedia). She is a founding member of FND society. She serves as an Editor in Frontiers in Neurology and Neuroscience Research and as a Peer Reviewer at Publon Academy.
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