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COVID-19 is a rapidly evolving global pandemic that has effected more than 2 million people worldwide so far. Recent studies indicate that the invasion of the respiratory tract occurs through the angiotensin converting enzyme 2 receptor. Interestingly, these receptors are highly expressed by the heart, and are involved in cardiac function mediated by the renin-angiotensin system as well as in the development of systemic hypertension and diabetes mellitus. Clinical manifestations of COVID-19 are dominated by respiratory symptoms including fever, cough, and shortness of breath, with potential development into severe pneumonia. In a group of patients, the disease can cause severe cardiovascular complications such as acute myocardial injury, myocarditis, arrhythmias, and venous thromboembolism. In addition, patients with pre-existing cardiovascular disease, diabetes mellitus, and congestive heart failure might have an increased risk of death. Therefore, understanding the mechanisms involved in cardiovascular injury caused by SARS-CoV-2 is paramount for the development of effective treatments in patients with cardiac disease.
Submission Process
• Special issue articles can include both original unpublished research articles and review articles related to the specific theme.
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