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Despite Injectable fillers are frequently used to restore volume and correct wrinkles in perioral region. As our understanding of the perioral region advances and procedures available for its treatment increase, we are more able to successfully treat the aged perioral region with minimal risk. Perioral enhancement with HA fillers led to sustained effect in terms of lip fullness, wrinkle, correction of nasolabial fold and 3D volume assessments, and high subject satisfaction. For their caratheristic Juvederm Volift™ with lidocaine and Juvederm Volbella™ with lidocaine are suitable for lip and perioral region according to the severity of the wrinkles and to the lip augmentation that we want to obtain.