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Gross anatomy, also known as macroscopic anatomy, is the study of the structure of the human body visible to the naked eye. It serves as the cornerstone of medical education, providing students with a fundamental understanding of human anatomy necessary for clinical practice. This review aims to provide a comprehensive overview of gross anatomy, including its historical significance, anatomical regions, organ systems, and clinical relevance. By elucidating the intricate details of gross anatomy, this article highlights its importance in medical education and clinical practice.