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Author(s): Yuanqiang Hao
Alzheimer’s disease (AD), as the most common progressive
neurodegenerative disorder, is pathologically characterized by deposition
of extracellular plaque composed of amyloid-β peptide (Aβ). Therefore,
the development of reliable assays for Aβ (both monomers and oligomers)
are important for the early differential diagnosis of dementia, predicting
the progression of AD, as well as monitoring the effectiveness of novel
anti-Aβ drugs for AD. Recently, our group has constructed several
analytical assays for sensing Aβ (both monomers and oligomers): by using aptamer- and thioninemodified gold nanoparticles (aptamer-Au-Th) as
the signing probe, we fabricated an antibody-aptamer sandwich assay
for electrochemical evaluation of levels of β-amyloid oligomers; based on
metal–organic frameworks as electrochemical signal probes, we developed
a sensitive aptasensor for the detection of β-amyloid oligomers; based on the
target-mediate aggreation of gold nanoparticle, we constructed a sensitive
colorimetric assay for β-amyloid oligomers; based on the specific binding
between Cu2+ and Aβ1−40, we proposed a colorimetric assay as well as a
fluorescent assay for Aβ1−40 monomer..
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