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A peritoneal simple mesothelial cyst is a very rare mesenteric cyst. Though the lesion being generally asymptomatic, it usually ranges between a few centimeters to 10 cm; however, occasionally it presents with various, non-specific symptoms, which makes correct pre-operative diagnosis difficult. We present a case of a giant peritoneal simple mesothelial cyst that was successfully managed by complete surgical excision without any known intra and post operative surgical complications.