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Numerous positive characteristics of harvests and domesticated animals and human hereditary infections emerge from various single nucleotide polymorphisms or different point transformations with heterogeneous base replacements at a similar locus. Current cytosine or adenine base editors can just achieve C-to-T (G-to-A) or A-to-G (T-to-C) replacements in the windows of target genomic destinations of life forms; accordingly, there is a need to foster base editors that can at the same time accomplish C-to-T and A-to-G replacements at the focusing in the vicinity.
