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A hangover is a syndrome of physical and mental symptoms that occurs after 8 to 16 hours of consumption with a zero level of alcohol. The aim of the current study is to investigate the effects of the alcohol hangover. The impairing effects on memory functioning such as delayed recall, irritation, lack of concentration and after acute alcohol intoxication. Normally the body might use cytokines to trigger a fever of inflammatory response to battle infection leading to unpleasant effects include nausea, vomiting, dizziness, fatigue and hormonal imbalance in the body. Dehydration is believed to be the cause of hangover as it leads to anti diuresis state in the body. The most compelling theory that, at the moment, is that hangover results from a buildup of acetaldehyde, a toxic compound in the body. The congener amount in the particular alcoholic beverage is believed to be increase the extent of severity of hangover. Methanol, found in highest levels in whiskey and red wine has received a larger amount of blame for showing that it can linger in the body after all alcohol has been eliminated, perhaps accounting for the enduring effects of hangover.