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Just a few months ago, the severe acute respiratory syndrome coronavirus 2, SARS-CoV-2 outbreaks began. It spread quickly, leading to a number of fatalities and morbidities. Despite numerous new particular publications being published every day, the virus's transmission mechanism is still not fully understood. The Angiotensin-converting enzyme 2 receptors are highlighted in this article as a potential route for viral transmission into the body through the oral cavity. It also offers recommendations for standard safety precautions to be taken when providing oral healthcare in dental offices.