Abstract

Gastric Carcinoma (GC) an aggressive tumor that carries a poor prognosis. GC is the 9^th commonest cancer reported in Pakistan.The aim of this study was to assess the risk factors, clinical characteristics and GC’s sub-types, seen at a premier tertiary care hospital in Karachi, Pakistan.

Methods:

This retrospective study included all histopathologically confirmed cases over a period of 5 years from April 2015 to April 2019. The data was analyzed using SPSS v21.

Results:

A total of 255 cases were identified, out of which 229 (89.8%) were adenocarcinoma (AC). In these 229 cases of AC; Male were 154 (60.6%) and female were 101 (39.4%). Their ages ranged from 19 to 95 years with a mean of 50.6±13.7. Epigastric pain and vomiting were the most common symptoms. Ascites was seen in 37 (31.9%). Most of the patients were belonging to the province of Sindh 193 (84.2%). Cigarette smoking was the most prominent risk factor in 76 (26.6%), followed by consumption of beetle nuts, pan and gutka 45 (18%). AC predominantly involved gastric antrum and pylorus 187 (73.3%).