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Anatomical anomalies, deviations from the typical structure of an organism, have increasingly emerged as significant contributors to disease pathology and clinical manifestations across various medical specialties. This research article provides a comprehensive overview of anatomical anomalies in disease, exploring their prevalence, etiology, and clinical implications. We delve into the diverse manifestations of anatomical anomalies within different organ systems and discuss their role in the pathogenesis of various medical conditions. Additionally, we examine the diagnostic challenges posed by anatomical anomalies, their impact on treatment strategies, and the potential for targeted interventions to improve patient outcomes. By synthesizing evidence from clinical studies, case reports, and experimental research, this article aims to deepen our understanding of the clinical significance and pathological implications of anatomical anomalies in disease.