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Anatomical differences refer to the natural variations and variations in anatomical structures among individuals. These differences can range from subtle variations in size and shape to more significant differences in the presence or absence of certain structures. Understanding anatomical differences is crucial in various fields, including medicine, surgery, anthropology, and forensic sciences. This mini review aims to explore the concept of anatomical differences, their implications, and the methods used to study and categorize these variations. The review discusses examples of anatomical differences in different regions of the body and their relevance in clinical practice. Additionally, it explores the genetic and environmental factors that contribute to anatomical variations. The review concludes by emphasizing the importance of recognizing anatomical differences to improve medical diagnoses, surgical outcomes, and personalized healthcare.