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Anatomical variability within populations reflects the diverse range of morphological traits observed among individuals, encompassing subtle variations to profound differences in anatomical structures. This research article provides a comprehensive examination of anatomical variability in populations, exploring its prevalence, determinants, and clinical implications across different demographic groups and geographic regions. We delve into the factors influencing anatomical variability, including genetic diversity, environmental influences, and developmental processes, and discuss their roles in shaping phenotypic diversity within populations. Additionally, we explore the clinical significance of anatomical variability in diagnostic imaging, surgical interventions, and personalized medicine, highlighting the importance of understanding population-specific anatomical variations for optimizing healthcare delivery and patient outcomes.