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Anatomical variability refers to the natural differences and deviations that can occur in the anatomy of individuals within a species. This mini-review manuscript aims to explore the significance of anatomical variability, its underlying causes, and its implications in various fields. We delve into genetic, developmental, and environmental factors that contribute to these variations, highlighting their relevance in medical practice, evolutionary biology, and beyond. By understanding anatomical variability, we can gain valuable insights into human diversity and pave the way for more personalized approaches in healthcare and research.