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Silver nanoparticles have many biological approaches. In our present study silver nanoparticles were used to treat the dextrose induced diabetic rats. Silver nanoparticles treated diabetic rats shoed good results. In this present study we got good results for glucose, SGPT and SGOT biochemical parameters. Diabetic rats treated with silver nanoparticles decreased the glucose levels. The SGOT and SGPT levels were decreased when treated with silver nanoparticles. The administration of silver nanoparticles was done with intra peritoneal injection to the rats. The diabetic rats treated with silver nanoparticles showed very low effect on lipid profile. Significant results obtained for LDL cholesterols. Silver nanoparticles decreased the LDL Cholesterol. Our present study showed the significant results for dextrose induced diabetic rats treated with silver nanoparticles.